It is Borussia Dortmunds fifth consecutive game without a win in all competitions.
Dortmund's lead over second-placed Bayern Munich has been cut after the champions beat Augsburg 3-2 on Friday night.
Nuremberg keeper Christian Mathenia frustrated Dortmund, denying Mario Gotze three times in 60 seconds - and once again after the break,
It is the first time Dortmund failed to score in back-to-back games in one season since March 2015.
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